Le Moyne College, named after Simon Le Moyne, is a private, Jesuit college enrolling over 3,500 undergraduate and graduate students. Founded by the Society of Jesus in 1946, Le Moyne is the first Jesuit college to be founded as a co-educational institution. The College is the second-youngest of the twenty-eight Jesuit colleges and universities in the United States, and is the only comprehensive Catholic college in Central New York.

The Le Moyne College 160-acre (0.65 km2) campus is located in a residential neighborhood of the Syracuse, New York suburb of DeWitt, New York, but also borders the Salt Springs neighborhood of Syracuse, New York, facilitating partnerships with the City of Syracuse and regional businesses and organizations.

Fred P. Pestello, Ph.D. is the 13th President of Le Moyne College and first permanent lay leader of the college, a position he accepted after a 24-year career at the University of Dayton.

On November 19, 2008, Le Moyne announced that it had received a gift of $50 million from the estate of Robert and Catherine McDevitt, longtime friends of the college who lived in Binghamton, NY. The legacy was designated for the support of the study of physics, computer science, information systems and religious philosophy. Neither of the McDevitts attended Le Moyne. Mr. McDevitt's mother was Mary Graiff McDevitt, secretary for A. Ward Ford, a board member of Computing Tabulating Recording Corporation. That company changed its name to IBM in 1924. The gift will be termed the McDevitt Endowment and more than doubles the school's current endowment fund. McDevitt's cousin, the late Rev. Edward L. McDevitt, S.J., helped establish Le Moyne's physics department when the college was founded.

On September 15, 2009, President Pestello announced the third largest gift in the history of the College, an anonymous donation of $4 million from an alumnus who wishes to support the College's OneLeMoyne strategic initiative.