Itawamba Community College, formerly known as Itawamba Junior College, is a community college in Mississippi, United States, with two campuses; the main campus is located in Fulton, and a branch campus in Tupelo that mainly handles technical education programs. It serves Chickasaw, Itawamba, Lee, Monroe, and Pontotoc counties. Itawamba Community College began as an extension of Itawamba County Agricultural High School, one of the largest high schools in Mississippi, which was organized in 1920. In 1941, the trustees extended the curriculum to provide for two years of college work. However, World War II postponed the plans for buildings and equipment to pursue college status. In March 1948, the boards of supervisors and school boards of Itawamba, Lee and Monroe counties unanimously and harmoniously agreed to support Itawamba Junior College. A full freshman college curriculum was offered for the first time during the 1948-49 session, and sophomore work, during 1949-50. Pontotoc County began supporting the institution in 1953, and Chickasaw County in 1972. Both counties have become a vital part of the institution.

The ICC Tupelo Campus, which was organized in July 1963, operated in vacant buildings and shops procured from businesses of the city of Tupelo. In July 1966, the school relocated into a 65,500-square-foot (6,090 m2) complex, which has grown to include 11 buildings. In the fall of 1987, the name of the institution was changed to Itawamba Community College to more adequately reflect its mission and purpose.

Itawamba Community College has a rich tradition of athletic excellence. ICC has an outstanding athletic program that offers nine sanctioned collegiate sports including football, men's and women's basketball, soccer, women's fast pitch softball, baseball, men's and women's tennis and golf. ICC's athletic programs are among the top in Mississippi's Community Colleges. This success is related to the commitment of the college, the support of the community and an outstanding athletic department. The athletic teams of Itawamba Community College are known as the Indians and the school's colors are red, white and navy. The men's and women's basketball teams began to play in the Davis Event Center in January 2007 and the Itawamba Community College Men's tennis program finished 15th in the Nation in the final NJCAA poll for the 2008 season.